HOW CAN YOU GET INVOLVED?

If your patient has consented to use of their sample in research on the Ambry Genetics Test Requisition Form or Consent form, provide a detailed clinical history of your patient. Register with AmbryShare to securely enter your patient’s clinical history details and freely access our data. Get more details here.

Register Now

Register to download the current AmbryShare data.

Enroll Your Patients in AmbryShare

Download Consent Forms for your Patients.

WHY GET INVOLVED?

The human genome holds a promise: complete understanding of human disease. Unfortunately, this promise is locked because critical data and knowledge are being hoarded. This is delaying progress.

It’s time to restore the balance between open science and commercial interests. With AmbryShare, we can break the mold to unlock the promise of the human genome.

Explore our AmbryShare database and download aggregated cohort data for free by registering. This allows you to search for alterations, review allele frequency within our disease cohorts, and access links to other publicly available disease and variant specific databases. We will also send updates on AmbryShare and any new disease cohort/aggregate data as they are available.

Access our aggregate data and our online resources. Patient-friendly websites and tools are available to help families understand genetics concepts and more. Use our online family history tool to create pedigrees that can accompany test orders.
Tell your patients about AmbryShare. They have the choice of consenting to allow their sample to be used in anonymized research or not. If they have questions about this research study, they may login to review information on AmbryShare. They may also be interested in checking out our pages with videos and resources created just for them.
Explore our AmbryShare database and download our data for free. Aggregate data will be shared, but individual data will not be.

STEPS TO GET INVOLVED

Want to get involved? Here are the steps to make it happen:

Frequently Asked Questions

The world would be a better place if all human disease was understood. We hope the scientific community finds utility in the AmbryShare database and dataset to better understand disease on their own and/or in collaboration with Ambry. We encourage the following groups to use this database:

  • Researchers and scientists: mine AmbryShare looking for candidate genes for new gene-disease relationships, variants for functional analysis or drug targets, and other important research goals.
  • Worldwide clinical and research laboratories performing variant assessment: leverage the AmbryShare database alongside other databases, to assess variants and assist in interpretation of results in AmbryShare, with the goal of understanding human disease.
  • Patients: to register with AmbryShare to receive updates, gain access to our family history tool, and take it to your healthcare provider to discuss if genetic counseling and/or testing is right for you.

Samples were selected from patient samples received at Ambry Genetics for clinical genetic testing, focused on breast and ovarian cancer. All patients consented to the use of their sample for research.

Yes, all patients included in this cohort consented to use of their DNA for research.

No. All data (clinical history and sequence data) has been de-identified, and available in AmbryShare in aggregate by variant and disease type. Here is an example of what the aggregate data would like for a particular variant (click image to enlarge):

Based on strict adherence to our protocol, which was IRB approved as exempt, only the type of disease the patient had will be provided (e.g. breast cancer).

  • No. We cannot determine which patients’ samples were included in the AmbryShare dataset.
  • To determine whether or not a particular patient consented for the use of their sample in research, please refer to your copy of their Ambry Genetics Test Requisition Form.

Please assure them that their information has been de-identified and is part of an aggregate. If Ambry wishes to use a patient’s data further, Ambry is obligated to obtain additional IRB approval to obtain explicit consent from an individual in order to do so. At that time, the patient can decline if they wish.

Patients may choose to opt in or out of their sample being used for research purposes on the Ambry Genetics Test Requisition Form. Samples from patients who opt in may be included in AmbryShare.

  • AmbryShare is a database of genetic and clinical information from individuals on whom Ambry Genetics performed exome sequencing (e.g. sequenced every gene in their body, focusing on their exome).
  • AmbryShare’s goal is to share enough data to help all human disease be understood, leading to treatments and cures.
  • Ambry has sequenced every gene in 10,000+ people with breast and/or ovarian cancer. All personally identifiable information has been removed from these data and they are grouped together, so no person can be identified from these data. If you have genetic testing through Ambry Genetics and indicate on the Test Requisition Form that you agree to Ambry using your sample for research, you sample could be included in AmbryShare. Your personally identifying information would not be connected to it.
  • This Institutional Research Board (IRB)-approved study was classified as “exempt” from full informed consent, but we chose to include samples from patients that consented to the use of their sample for research. We specifically excluded samples from patients that asked for their sample NOT to be used in research.
  • What if my patients asks for his/her sample to be removed from AmbryShare?
    • Please assure them that their information has been anonymized and is part of an aggregated dataset. If Ambry wishes to use a patient’s data further, Ambry is obligated to obtain additional IRB approval to obtain explicit consent from an individual in order to do so. At that time, the patient can decline if they wish.
  • What will happen to my patients sample when it is sent to Ambry for clinical genetic testing?
    • Samples sent to Ambry for clinical genetic testing may be used for research purposes only if the patient agrees to the use of their sample for research purpose and this is indicated on the Test Requisition Form. Research may include the use of the sample for internal training and validation, inclusion in AmbryShare dataset, or other research purposes.

Let People Know

Tell your patients and colleagues you have registered
with AmbryShare
, and ask them to register as well!

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